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| 湖北省肿瘤登记地区2021年肝癌发病和死亡特征及2012-2021年变化趋势分析 |
| Analysis of the Epidemic Characteristics of Liver Cancer in registration areas in 2021 and the Trends from 2012 to 2021 in Hubei Province |
| 投稿时间：2026-01-28 修订日期：2026-06-23 |
| DOI： |
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| 中文关键词: 肝癌 发病率 死亡率 趋势分析 湖北 |
| 英文关键词:liver cancer incidence mortality trend analysis Hubei |
| 基金项目: |
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| 摘要点击次数: 8 |
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| 中文摘要: |
| [目的]分析湖北省2021年肿瘤登记地区肝癌发病和死亡特征以及其2012-2021年变化趋势，为肝癌防治提供科学支持。
[方法]利用2021年湖北省31个肿瘤登记处上报的肝癌发病及死亡数据，计算肿瘤登记地区肝癌发病率和死亡率及其中标率、世标率以及0~74岁累积率等指标。分析2012-2021年湖北省肿瘤登记地区肝癌中标发病率、死亡率及其年度变化百分比（annual percentage change, APC）、平均年度变化百分比（average annual percentage change, AAPC）及其95%置信区间（confidence interval, CI）。
[结果]2021年湖北省肿瘤登记地区新发肝癌6721例，占全部新发恶性肿瘤的7.91%，发病率为26.07/10万，中标及世标发病率分别为13.76/10万、15.11/10万，0~74岁累积发病率为1.60%。2021年湖北省肿瘤登记地区肝癌死亡6394例，占全部恶性肿瘤死亡的13.51%，死亡率为24.80/10万，中标及世标死亡率、率分别为12.7910万、14.23/10万，0~74岁累积死亡率为1.47%。
2021年湖北省肿瘤登记地区肝癌的发病、死亡水平均呈现男性高于女性、农村高于城市的态势，且均随着年龄的增长而升高，并分别在75~79岁、80~84岁年龄组达到顶峰。2012-2021年，湖北省肿瘤登记地区肝癌中标发病率（AAPC发病=-4.66%，95%CI：-5.34%~-3.79%）和死亡率（AAPC死亡=-3.65%，95%CI：-4.01%~-3.22%）呈连续下降趋势，总体下降幅度分别为35.73%、28.37%，其中肝癌中标发病率在2016-2021年下降趋势显著（APC发病=-6.00%，95%CI：-8.66%~-5.07%），中标死亡率（APC死亡=-5.23%，95%CI：-6.00%~-4.74%）则在2015-2021年间有显著下降趋势。
[结论]湖北省肿瘤登记地区肝癌发病及死亡水平性别、城乡差异明显，且随着年龄增长而升高。近10年来，湖北省肿瘤登记地区肝癌发病率和死亡率呈现明显下降趋势，但肝癌绝对负担仍较重，应继续加强肝癌的综合防控措施，持续降低肝癌疾病负担。 |
| 英文摘要: |
| [Purpose] To Analyze the epidemiological characteristics of liver cancer in the cancer registration areas of Hubei Province in 2021 and the incidence and mortality trends of liver cancer from 2012 to 2021 to provide scientific support for the prevention and treatment of liver cancer.
[Methods] The incidence and mortality data of liver cancer reported by 31 cancer registries in Hubei Province in 2021 was utilized to calculate the incidence rate, mortality rate, standardized incidence rate, standardized mortality rate, and cumulative incidence rate for ages 0~74 and estimate the number of liver cancer cases and deaths in Hubei Province in 2021. We analyzed the age-standardized incidence and mortality rate by Chinese standard population (ASIRC, ASMRC), annual percentage change (APC), average annual percentage change (AAPC), and 95% confidence interval (CI) of liver cancer in the cancer registration areas of Hubei Province from 2012 to 2021.
[Results] In 2021, there were 6721 new cases of liver cancer in registration areas of Hubei Province, accounting for 7.91% of all new cases of malignant tumors. The incidence was 26.07/105, ASIRC (age-standardized incidence rate by Chinese standard population) and WSIRC (age-standardized incidence rate by world standard population) was 13.76/105 and 15.11/105, respectively. The cumulative incidence rate for individuals aged 0 to 74 was 1.60%.There were 6394 liver cancer deaths in registration areas of Hubei Province in 2021, accounting for 13.51% of all malignant tumor deaths. The mortality rate was 24.80/105, with the ASMRC (age-standardized mortality rate by Chinese standard population) and the ASMRW (age-standardized mortality rate by world standard population) being 12.79/105 and 14.23/105, respectively. The cumulative mortality rate for people aged 0 to 74 was 1.47%.
In 2021, the incidence and mortality level of liver cancer in cancer registration areas of Hubei Province showed a trend of being higher in males than in females, and higher in rural areas than in urban areas. Both of incidence and mortality rate increased with age, and reaching peaks at the age group of 75 to 79 and 80 to 84, respectively. From 2012 to 2021, the ASIRC (AAPC incidence = -4.66%, 95%CI: -5.34% to -3.79%) and ASMRC (AAPC mortality = -3.65%, 95%CI: -4.01% to -3.22%) of liver cancer in registration areas of Hubei Province showed a continuous downward trend. The decrease of liver cancer incidence and mortality over the 10-year period was 35.73% and 28.37%, respectively. Among them, the ASIRC (APC incidence = -6.00%, 95%CI: -8.66% to -5.07%) and ASMRC (APC mortality = -5.23%, 95%CI: -6.00% to -4.74%) of liver cancer decreased significantly between 2016 and 2021 and 2015 and 2021.
[Conclusion] In registration areas of Hubei Province, there are significant gender differences in incidence and mortality levels of liver cancer, which increase with age. Over the latest 10 years, the incidence and mortality rates of liver cancer in registration areas of Hubei Province have shown a notable downward trend, However, the absolute burden of liver cancer remains heavy. Therefore, it is necessary to continue strengthening comprehensive prevention and control measures for liver cancer to continuously reduce the disease burden. |
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