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| 2022年甘肃省武威市女性乳腺癌流行特征及2010—2022年变化趋势分析 |
| Analysis of Epidemiological Characteristics of Female Breast Cancer in Wuwei City, Gansu Province, 2022 and Its Trends from 2010 to 2022 |
| 投稿时间：2026-01-13 修订日期：2026-03-13 |
| DOI： |
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| 中文关键词: 乳腺癌 发病率 死亡率 甘肃 |
| 英文关键词:Breast cancer Incidence Mortality Gansu |
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| 中文摘要: |
| 摘 要：[目的]分析2022年甘肃省武威市女性乳腺癌的流行情况及2010-2022年武威市女性乳腺癌的流行趋势。[方法]按照国家癌症中心制定的数据质量审核评价标准，对武威市符合质量控制标准要求的肿瘤登记点上报的乳腺癌发病、死亡和人口数据进行汇总分析，分地区、年龄计算发病及死亡率及其标化率。采用Joinpoint线性回归模型计算2010-2022年武威市女性乳腺癌发病率、死亡率的年度变化百分比（annual percentage change，APC）、平均年度变化百分比（average annual percentage change，AAPC）及 95%置信区间（confidence interval，CI），分析乳腺癌发病和死亡趋势。[结果]2022 年甘肃省武威市肿瘤登记点的女性乳腺癌在女性癌症发病谱中位列第 1，新发病例达 248 例，发病率为 28.86/10 万，中国标准人口发病率（中标发病率）为 18.80/10 万，世界标准人口发病率（世标发病率）为 18.94/10 万，0-74 岁累计发病率为 1.82%。其中，城市与农村地区的女性乳腺癌中标发病率分别为 17.18/10 万和 22.04/10 万。死亡病例 67 例，死亡率为 7.80/10 万，中标死亡率为 4.48/10 万，世标死亡率为 4.84/10 万，0-74 岁累计死亡率为 0.49%。城市和农村地区的乳腺癌中标死亡率分别为 4.23/10 万和 4.91/10 万。2010-2022年，甘肃省武威市女性乳腺癌整体标化后发病率呈下降趋势（APC=-3.26%,P=0.02)，且变化趋势有统计学意义。粗死亡率在2010~2022年呈现下降趋势（APC=-8.99%,P=0.03)，标化后死亡率也呈下降趋势（APC=-9.16%,P=0.04)，且变化都有统计学意义。2010—2022 年，该市乳腺癌发病峰值集中于 45~54 岁年龄段。[结论]2022 年武威市女性乳腺癌发病位居前列，城乡发病、死亡存在差异。需持续监测发病死亡趋势，针对城乡差异优化防控策略，强化早筛早治，降低疾病负担。 |
| 英文摘要: |
| Abstract:[Objective]?To analyze the epidemiological characteristics of female breast cancer in Wuwei City, Gansu Province, in 2022, and to examine its trends from 2010 to 2022.[Methods]?Based on the data quality review and evaluation standards established by the National Cancer Center, data on breast cancer incidence, mortality, and population reported by qualified tumor registries in Wuwei City were aggregated and analyzed. Incidence and mortality rates, along with age-standardized rates, were calculated by region and age group. The Joinpoint linear regression model was used to compute the annual percentage change (APC), average annual percentage change (AAPC), and 95% confidence intervals (CI) for female breast cancer incidence and mortality in Wuwei from 2010 to 2022, in order to analyze trends in breast cancer incidence and mortality.[Results]?In 2022, female breast cancer ranked first among all cancers in women in the tumor registries of Wuwei City, Gansu Province, with 248 new cases. The crude incidence rate was 28.86/10?, the age-standardized incidence rate by Chinese standard population (ASIRC) was 18.80/10?, and the age-standardized incidence rate by world standard population (ASIRW) was 18.94/10?. The cumulative incidence rate for ages 0–74 was 1.82%. The ASIRC in urban and rural areas was 17.18/10? and 22.04/10?, respectively. There were 67 deaths, with a crude mortality rate of 7.80/10?, an ASIRC of 4.48/10?, and an ASIRW of 4.84/10?. The cumulative mortality rate for ages 0–74 was 0.49%. The ASIRC for breast cancer mortality in urban and rural areas was 4.23/10? and 4.91/10?, respectively. From 2010 to 2022, the overall age-standardized incidence rate of female breast cancer in Wuwei showed a declining trend (APC = –3.26%, P = 0.02), which was statistically significant. The crude mortality rate also declined during this period (APC = –8.99%, P = 0.03), as did the age-standardized mortality rate (APC = –9.16%, P = 0.04), both with statistical significance. From 2010 to 2022, the peak incidence of breast cancer in the city occurred in the 45–54 age group.[Conclusion]?In 2022, breast cancer was the leading cancer among women in Wuwei City, with notable differences in incidence and mortality between urban and rural areas. Continuous monitoring of incidence and mortality trends is essential. Prevention and control strategies should be optimized according to urban–rural disparities, with emphasis on early screening and treatment to reduce the disease burden. |
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