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| 整合炎症与营养：那不勒斯预后评分在肺癌中的研究进展与临床价值 |
| Integrating Inflammation and Nutrition: Research Progress and Clinical Value of the Naples Prognostic Score in Lung Cancer |
| 投稿时间：2025-12-17 修订日期：2026-02-24 |
| DOI： |
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| 中文关键词: 那不勒斯评分 肺癌 预后 |
| 英文关键词:naples prognostic score (NPS) lung cancer prognosis |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 肺癌作为全球癌症相关死亡的首要原因，目前预后评估体系仍主要依赖TNM分期，缺乏对患者全身炎症与营养状态的系统整合。那不勒斯预后评分（naples prognostic score, NPS）作为一种整合炎症与营养指标的综合预测系统，已在多种实体瘤中证实其预后预测价值。本综述系统梳理NPS在肺癌预后评估中的研究进展，探讨其生物学机制、临床适用性及局限性，以推动其从研究向临床实践的转化，为肺癌个体化治疗提供新视角。 |
| 英文摘要: |
| Lung cancer remains the leading cause of cancer-related mortality worldwide. Currently, prognostic evaluation relies primarily on the TNM staging system, which lacks a systematic integration of the patient""s systemic inflammatory and nutritional status. The Naples Prognostic Score (NPS), as a comprehensive predictive system that integrates inflammatory and nutritional indicators, has demonstrated its prognostic value across various solid tumors. This review systematically summarizes the research progress of NPS in the prognostic assessment of lung cancer, exploring its underlying biological mechanisms, clinical applicability, and limitations. The objective is to facilitate the translation of NPS from research into clinical practice, providing a new perspective for the personalized treatment of lung cancer. |
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