|
| mRNA疫苗在NSCLC中的应用与挑战 |
| Application and challenges of mRNA vaccines in non-small cell lung cancer |
| 投稿时间：2025-09-29 修订日期：2025-12-29 |
| DOI： |
|
 |
| 中文关键词: mRNA疫苗 NSCLC 脂质纳米颗粒 联合治疗 |
| 英文关键词:mRNA vaccine non-small cell lung cancer lipid nanoparticles combination therap |
| 基金项目:国家重点基础研究发展计划（973计划）,国家自然科学基金项目（面上项目，重点项目，重大项目） |
|
| 摘要点击次数: 11 |
| 全文下载次数: 0 |
| 中文摘要: |
| 非小细胞肺癌是全球癌症相关死亡的主要原因，由于肿瘤的异质性和免疫抑制微环境，传统疗法会产生耐药性。mRNA 疫苗作为一种新型免疫疗法，通过激活针对肿瘤特异性抗原（TSAs）或肿瘤相关抗原（TAAs）的抗肿瘤免疫反应，显示出治疗 NSCLC 的新方向。本文系统回顾了mRNA疫苗的技术原理、临床前研究和临床试验结果，探讨了mRNA疫苗在NSCLC中面临的主要挑战，包括抗原逃逸、递送效力不足和联合治疗策略的优化等问题。未来,需要通过技术创新和多学科研究来促进 mRNA 疫苗的临床应用。 |
| 英文摘要: |
| Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths globally, with resistance to conventional therapies due to tumour heterogeneity and an immunosuppressive microenvironment.mRNA vaccines, as a novel immunotherapy, show unique potential for the treatment of NSCLC by activating anti-tumour immune responses against tumour-specific antigens (TSAs) or tumour-associated antigens (TAAs).This paper systematically reviews the technical principles, preclinical studies and clinical trial results of mRNA vaccines, and discusses the major challenges faced by mRNA vaccines in NSCLC, including antigen escape, insufficient delivery efficacy and optimisation of combination therapy strategies.In the future, technological innovation and multidisciplinary research are needed to promote the clinical application of mRNA vaccines. |
|
在线阅读
查看/发表评论 下载PDF阅读器 |
|
|
|