| Background and Objective: To evaluate the long-term follow-up data of esophageal cancer patients who underwent surgical treatment based on hospital registration, and provide the latest real-world evidence for the postoperative survival status of esophageal cancer. Methods: The study included 2,598 patients diagnosed with esophageal cancer who underwent radical surgical treatment at Zhejiang Cancer Hospital between January 1, 2015, and December 31, 2021. Basic patient information, clinical characteristics and follow-up survival data were collected. Follow-up data were collected through November 19, 2024. The Kaplan-Meier method was used to estimate the 1-year, 3-year and 5-year overall survival (OS) rates after surgery. The Log-rank test was used to compare the survival differences across subgroups including age, sex, surgical approach, pathological stage and so on. Results: After a median follow-up of 5.18 years, the overall 1-year, 3-year and 5-year OS rates of esophageal cancer patients after surgery were 87.02%, 64.14% and 55.55% respectively. The 5-year OS rates of surgical patients with stage 0-Ⅳ esophageal cancer were 94.44%, 75.22%, 62.94%, 38.05% and 12.72% respectively. Statistically significant survival differences were observed across subgroups stratified by sex, age, surgical year, incision type, surgical approach, differentiation grade, histologic subtype, and advanced-stage gross classification. Conclusion: This study firstly reported the long-term postoperative survival outcomes of esophageal cancer patients in a large, hospital registry-based sample from Zhejiang Province, which provides real-world evidence for evaluating the quality of cancer diagnosis and treatment. |
