| Traditional cardio-oncology has primarily focused on the impact of cancer and its related therapies on cardiovascular health. However, emerging clinical and preclinical evidence suggests that cardiovascular diseases (CVD) may, in turn, promote tumor initiation and progression. This has led to the introduction of the novel concept of “reverse cardio-oncology”, which aims to investigate the influence of CVD and their therapeutic interventions on tumor development. Evidence indicates that pathological processes such as early cardiac remodeling and myocardial infarction may accelerate tumor progression, although the precise mechanisms underlying CVD-facilitated tumorigenesis remain to be fully elucidated. This review systematically summarizes the potential mechanisms by which CVD, related pharmacotherapies, and clinical interventions contribute to tumor development, and discusses the value of cardiovascular biomarkers in the interdisciplinary field of cancer research, with the goal of providing new perspectives for advancing the study of reverse cardio-oncology. |
