| [Objective]? This study aimed to analyse compliance with lung cancer screening and its associated influencing factors among residents of Yangzhong City between March 2024 and May 2025.?[Methods] Cluster sampling was employed to recruit permanent residents aged 40–74 years across the entire administrative area of Yangzhong City. Participants completed a questionnaire, registered for screening, and eligible individuals were invited to undergo chest low-dose spiral computed tomography (LDCT). The screening compliance of different characteristic groups was compared using the χ2 test, and multivariate logistic regression analysis was employed to identify independent factors influencing compliance. [Results]??A total of 15,764 individuals were included in the analysis, of whom 11,597 were covered by non-employee basic medical insurance and 4,167 were covered by employee basic medical insurance. The overall screening compliance rate was 75.86% (11,959/15,764); specifically, the rate was 79.81% (9,256/11,597) among those with non-employee basic medical insurance and 64.87% (2,703/4,167) among those with employee basic medical insurance. Multivariate logistic regression analysis revealed that, in the total population, individuals with employee basic medical insurance and male participants exhibited significantly lower screening compliance (both P<0.05). In contrast, factors associated with higher compliance included older age, rural residency, a family size of 4–7 members, an average annual household income of 30,000–69,900 yuan, a history of occupational exposure, weekly consumption of fresh vegetables and fruit, regular physical exercise, and a family history of lung cancer in first-degree relatives (all P<0.05). Furthermore, stratified analysis revealed that there were partial differences in the factors influencing screening compliance between the group with non-employee basic medical insurance and the group with employee basic medical insurance. However, except for educational attainment, the direction of the impact of these factors on compliance was consistent with that observed in the total population. [Conclusions]?The overall compliance of residents in Yangzhong City with lung cancer screening is satisfactory, though there remains room for improvement. Based on the characteristics of factors influencing compliance, it is recommended that screening compliance and effectiveness among the general population be further enhanced by adopting flexible screening schedules, scaling up the successful experience of targeted outreach in rural areas, developing personalized intervention plans for groups with low compliance, and continuously optimizing the quality of screening services. |