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| 辽宁庄河地区2008-2020年胃癌发病率及死亡率趋势分析 |
| Analysis of Incidence and Mortality Trends of Gastric Cancer in Zhuanghe, Liaoning Province from 2008 to 2020 |
| 投稿时间：2024-08-09 修订日期：2024-08-24 |
| DOI： |
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| 中文关键词: 胃癌，筛查，发病率，死亡率，庄河 |
| 英文关键词:Gastric cancer, screening, morbidity, mortality,Zhuanghe |
| 基金项目:“十四五”国家重点研发计划 (2022YFC2505100, 2016YFC1303200) 、辽宁省重点研发计划(2020JH2/10300063)、中央补助地方重大公共卫生事业专项（2008-2023） |
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| 中文摘要: |
| [目的] 分析辽宁省庄河市2008-2020年胃癌发病、死亡情况以及年代变化趋势。[方法] 利用庄河市疾病预防控制中心“肿瘤登记报告和死因监测系统”收集的2008-2020年胃癌发病与死亡数据，分别统计胃癌发病和死亡例数，计算粗发病率/死亡率、中国人口标准化率(中标率)和世界人口标准化率(世标率)。采用Joinpoint软件进行回归分析，计算2008-2020年胃癌发病与死亡的年度平均变化百分比（Average Annual Percentage Change, AAPC）。[结果] 2008-2020年庄河地区胃癌新发病例共计5650例，男女发病比为2.7:1；因胃癌死亡病例共计3465例，男女死亡比为2.73:1。2008-2020年间，庄河胃癌发病率、死亡率均呈现显著下降趋势，其中，世标发病率和中标发病率分别从2008年的34.97/10万和31.15 /10万降至2020年的18.69/10万和16.40/10万（世标AAPC=-3.9%，95%CI-5～-2.7，P<0.001；中标AAPC=-3.9%，95%CI -5.2～-2.6，P<0.001），而世标死亡率和中标死亡率分别从2008年的19.64/10万和17.07 /10万降至2020年的14.05/10万和11.84/10万（世标AAPC=-3.7%，95% CI-5.0～-2.4，P<0.001；中标AAPC=-4 %，95%CI -5.4～-2.5，P<0.001）。2008～2020年，庄河胃癌发病率、死亡率均随年龄增长而增加。40岁以上组性中，男性年龄别发病率和死亡率均高于女性。40～64岁、65岁～组胃癌发病率、胃癌死亡率均随时间呈下降趋势。[结论] 2008-2020年庄河市胃癌发病、死亡呈明显下降趋势，但死亡率仍高于全国平均水平。需继续完善恶性肿瘤监测系统，加强胃癌高危人群的健康宣教及综合防治工作，有针对性地开展胃癌病因识别和筛查早诊早治工作，进一步降低死亡率。 |
| 英文摘要: |
| ［Purpose］To investigate the incidence, mortality and temporal trends of gastric cancer in Zhuanghe City, Liaoning Province, from 2008 to 2020.［Methods］Data on gastric cancer incidence and mortality from 2008 to 2020 were collected from the "Cancer Registry Report and Cause of Death Surveillance System" of the Zhuanghe Center for Disease Control and Prevention. We analyzed the numbers of gastric cancer cases and deaths, and calculated the crude incidence/mortality rates, age-standardized rate by world standard population(ASRW), and age-standardized rate by Chinese standard population(ASRC). The Joinpoint regression model was employed to compute the average annual percentage change (AAPC) in order to analyze the trends of gastric cancer incidence and mortality in Zhuanghe.［Results］
From 2008 to 2020, a total of 5,650 new gastric cancer cases were reported in Zhuanghe, with a male-to-female incidence ratio of 2.7:1. There were 3,465 deaths due to gastric cancer, with a male-to-female mortality ratio of 2.73:1. Both the incidence and mortality rates of gastric cancer in Zhuanghe showed a significant downward trend from 2008 to 2020. The ASRW and ASRC of incidence decreased from 34.97/105 and 31.15/105 in 2008 to 18.69/105 and 16.40/105 in 2020, respectively (ASRW AAPC = -3.9%, 95% CI -5 to -2.7, P < 0.001; ASRC AAPC = -3.9%, 95% CI -5.2 to -2.6, P < 0.001). The ASRW and ASRC of mortality decreased from 19.64/105 and 17.07/105 in 2008 to 14.05/105 and 11.84/105 in 2020, respectively (ASRW AAPC = -3.7%, 95% CI -5.0 to -2.4, P < 0.001; ASRC AAPC = -4%, 95% CI -5.4 to -2.5, P < 0.001). From 2008 to 2020, the incidence and mortality rates of gastric cancer increased with age. Age-specific incidence and mortality rates for males aged 40 years and older were higher than those for females. The incidence and mortality rates of gastric cancer in the 40-64 and 65+ age groups showed a decreasing trend over time.［Conclusion］From 2008 to 2020, there was a noticeable decline in the incidence and mortality rates of gastric cancer in Zhuanghe City, although the mortality rate remains higher than the national average. It is essential to continue improving the malignant tumor monitoring system, enhance health education and comprehensive for high-risk populations, and conduct targeted identification, screening, early diagnosis, and gastric cancer to further reduce mortality rates. |
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