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| 2008-2019辽宁庄河筛查人群幽门螺杆菌感染状况及其变化趋势分析 |
| The status and change trend of Helicobacter pylori infection in screening population in Zhuanghe, Liaoning Province from 2008 to 2019 |
| 投稿时间：2024-08-09 修订日期：2024-09-02 |
| DOI： |
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| 中文关键词: 庄河，筛查，幽门螺杆菌，年代变化，影响因素 |
| 英文关键词:Zhuanghe, screening, Helicobacter pylori, temporal changes, influencing factors |
| 基金项目:十四五”国家重点研发计划课题(2022YFC2505102），辽宁省财政厅科技专项（辽财企[2008]621号），中央补助地方重大公共卫生事业专项（2008-2023），沈阳市科技计划项目（22-321-32-03） |
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| 中文摘要: |
| ［目的］分析辽宁庄河地区人群Hp感染状态的变化趋势，并探讨Hp感染的影响因素。［方法］纳入2008年1月至2019年12月期间在庄河地区进行胃癌筛查的受检者，采用ELISA法检测血清抗Hp抗体-IgG，判定Hp感染情况。所有受检者均接受胃镜检查，常规HE染色及病理组织学诊断。［结果］从2008年至2019年，庄河地区接受筛查且进行Hp抗体-IgG检测的受检者共计13552例，其中男性5794例，女性7758例，受检者年龄范围为40至69岁，中位年龄为55岁。男性受检者Hp感染阳性者2183（37.68%），女性受检者Hp感染阳性者2741例（35.33%），男性高于女性患者（P=0.005）。在40-49岁和50-59岁年龄组间Hp感染率无差异（P=0.765），但均高于60-69岁年龄组（P=0.013,P=0.003)。基本正常人群Hp感染阳性率为32.33%，肠化型萎缩性胃炎和胃癌患者Hp感染阳性率分别为48.51%和56.72%，高于基本正常人群（P<0.001）。2008-2011年，2012-2015年以及2016-2019年间受检人群Hp感染阳性率分别为42.15%，34.01%和28.96%，随时间推移，Hp感染阳性率呈降低趋势。［结论］庄河筛查人群Hp感染与年龄、性别、胃疾病状态具有一定相关性，12年间该地区Hp感染阳性率呈降低趋势。 |
| 英文摘要: |
| [Objective] To analyze the trend of Helicobacter pylori (Hp) infection status in the population of Zhuanghe, Liaoning, and to explore the factors influencing Hp infection. [Methods] Individuals screened for gastric cancer in the Zhuanghe area from January 2008 to December 2019 were included. Serum anti-Hp antibody-IgG was detected by ELISA to determine Hp infection status. All subjects underwent gastroscopy, routine hematoxylin and eosin staining, and histopathological diagnosis. [Results] From 2008 to 2019, a total of 13,552 individuals underwent screening and Hp antibody-IgG testing in the Zhuanghe area, including 5,794 males and 7,758 females, with ages ranging from 40 to 69 years and a median age of 55 years. Hp infection was positive in 2,183 (37.68%) male subjects and 2,741 (35.33%) female subjects, with males showing higher infection rates than females (P=0.005). There was no difference in Hp infection rates between the age groups 40-49 and 50-59 years (P=0.765), but both were higher than in the 60-69 year age group (P=0.013, P=0.003). The positive rate of Hp infection in the general healthy population was 32.33%, while it was 48.51% in those with atrophic gastritis and 56.72% in gastric cancer patients, both higher than in the general healthy population (P<0.001). The positive rates of Hp infection in the periods 2008-2011, 2012-2015, and 2016-2019 were 42.15%, 34.01%, and 28.96% respectively, showing a decreasing trend over time. [Conclusion] Hp infection in the screening population in Zhuanghe area is correlated with age, gender, and gastric disease status, showing a decreasing trend over 12 years. |
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