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| 2010-2021辽宁庄河市胃癌筛查人群胃黏膜病变病理变化谱分析 |
| Analysis of Pathological Changes in Gastric Mucosal Lesions Among the Gastric Cancer Screening Population in Zhuanghe, Liaoning (2010-2021) |
| 投稿时间：2024-08-09 修订日期：2024-08-29 |
| DOI： |
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| 中文关键词: 庄河，筛查，胃黏膜病变，病理谱，年代变化 |
| 英文关键词:Zhuanghe, screening, gastric mucosal lesions, pathological spectrum, temporal changes |
| 基金项目: |
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| 摘要点击次数: 54 |
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| 中文摘要: |
| ［目的］通过对辽宁庄河现场2010年至2021年胃癌筛查人群的胃黏膜病变谱变化进行分析，揭示该地区胃癌发病的潜在规律。［方法］纳入2010年1月至2021年12月期间的辽宁庄河现场胃癌筛查受检者，所有受检者均按照筛查方案接受了胃镜检查和/或活检取材。计算不同病变构成比，分析辽宁庄河市胃癌筛查人群胃黏膜病变病理谱特征；应用Joinpoint回归模型分析其时间变化趋势。［结果］胃癌筛查受检者共20986例，女性比例高于男性，且≥50岁者居多。非萎缩性胃黏膜病变女性多见，但病变进展后男女比例趋于一致。上皮内瘤变及胃癌中男性占比更高。随病变发展，患者年龄上升，高级别上皮内瘤变和胃癌组高龄患者占比最多。2010年至2021年间，庄河地区胃黏膜病变谱随年代有所变化，非萎缩性胃黏膜病变占比上升，萎缩性胃黏膜病变占比下降。高级别上皮内瘤变和胃癌检出占比上升。胃癌的检出率和早诊率均随年代发展呈现出显著的增长趋势。［结论］2010-2021年庄河市胃黏膜病变谱构成呈现由重到轻的变化趋势，胃癌及其癌前病变早诊率显著提高。 |
| 英文摘要: |
| ［Purpose］To analyze the pathological spectrum of gastric diseases among individuals undergoing gastric cancer screening in Zhuanghe, Liaoning Province from 2010 to 2021, and to reveal the potential patterns of gastric cancer incidence in this region.［Methods］Participants undergoing gastric cancer screening in Zhuanghe, Liaoning Province from January 2010 to December 2021 were included in the study. All participants underwent endoscopic examination and/or biopsy according to the screening protocol. The proportion of different lesions was calculated to analyze the pathological spectrum characteristics of gastric mucosal lesions in the gastric cancer screening population in Zhuanghe, Liaoning Province. The temporal trend was analyzed using the Joinpoint regression model.［Results］A total of 20,968 participants were included, with a higher proportion of females than males, and the majority being aged 50 years or older. Non-atrophic gastric mucosal lesions were more prevalent among females, but the gender ratio evened out with disease progression. Intraepithelial neoplasia and gastric cancer were more common in males. As the lesions progressed, the age of patients increased, with the highest proportion of elderly patients found in the high-grade intraepithelial neoplasia and gastric cancer groups. From 2010 to 2021, the spectrum of gastric mucosal lesions in Zhuanghe varied over time, with an increase in the proportion of non-atrophic diseases and a decrease in atrophic mucosal lesions. The detection rates of high-grade intraepithelial neoplasia and gastric cancer increased. Both the detection rate and early diagnosis rate of gastric cancer showed significant upward trends over the years.［Conclusion］From 2010 to 2021, the spectrum of gastric mucosal lesions in Zhuanghe showed a trend of shifting from more severe to milder conditions, with a significant improvement in the early diagnosis rate of gastric cancer and its precancerous lesions. |
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