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江苏省启东市胆囊癌1972－2021年发病趋势分析

Long-term Trend of Gallbladder Cancer incidence rate in Qidong from 1972 to 2021

投稿时间：2024-05-06 修订日期：2024-07-07

DOI：

中文关键词: 胆囊癌癌症登记发病率趋势

英文关键词:Gallbladder Cancer Cancer registration incidence rates Qidong

基金项目:南通市“十四五”科教强卫工程（通卫科技〔2021〕15 号）南通市卫生健康委员会科研课题

作者	单位	邮编
徐源佑	启东市人民医院	226200
张永辉	启东市人民医院	226200
丁璐璐	启东市人民医院	226200
陈永胜	启东市人民医院	226200
王军	启东市人民医院	226200
严永锋	启东市人民医院	226200
陈建国	启东市人民医院	226200
朱健^*	启东市人民医院	226200

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中文摘要:

[摘要] 目的对启东1972－2021年全人群胆囊癌病例进行发病率分析，为预后评价及防治提供依据。方法使用来自启东市肿瘤登记数据库里的1972-2021年胆囊癌的发病资料，计算发病粗率(crude rate，CR)、中国人口标化率（age-standardized rate by Chinese standard population， ASRC)、世界人口标化率（age-standardized rate by world standard population， ASRW)等统计指标。用Joinpoint 4.9.1.0软件进行趋势分析，计算胆囊癌发病率年度变化百分比(APC)，对胆囊癌总体发病率、分性别及分年龄别发病率作时间趋势分析，判断率的长期趋势变化是否存在统计学差异。结果启东市1972-2021年胆囊癌共发病1369例，占全部恶性肿瘤发病的0.93%；50年间胆囊癌总CR为2.44/10万，总ASRC为0.88/10万，总ASRW为1.45/10万，35-64岁截缩发病率为1.98/10万，0-74岁胆囊癌累积发病率为0.16%，胆囊癌累积发病风险为0.16%。男性发病率明显高于女性，CR、ASRC和ASRW的性别比依次为0.89、1.07和1.06 。各个年龄组随着年龄的增加，胆囊癌发病率也不断增加。胆囊癌发病年龄略有提升。胆囊癌总体、男女性以及各个年龄组的发病率在50年间均有着明显的上升趋势。结论 50年间启东市全人群胆囊癌的发病率有了较大的提高，高年龄组发病率高于低年龄组，应当继续重视尤其是针对重点人群胆囊癌的防治研究。

英文摘要:

[Abstract] Purpose To analyse the incidence rate of Gallbladder cancer cases in the whole population of Qidong from 1972 to 2021 to provide a basis for prognostic evaluation and prevention. Methods The incidence data of Gallbladder and Biliary Tract cancer from 1972-2021 from the Qidong City Tumour Registry database were used to calculate statistical indicators such as crude rate (CR), age-standardized rate by Chinese standard population (ASRC), age-standardized rate by world standard population (ASRW), and so on. Trend analysis was performed using Joinpoint 4.9.1.0 software to calculate the annual percentage change (APC) of Gallbladder cancer incidence rates, and time trend analysis was performed on the overall incidence rate of Gallbladder cancer, the incidence rate by gender and age, to determine whether there was a statistically significant difference in the long-term trend of the rate. Results 1,369 cases of gallbladder cancer occurred in Qidong City from 1972-2021, accounting for 0.93%of the onset of all malignant tumors; the total CR of gallbladder cancer was 244/100,000 in 50 years, total ASRC was 088/100,000, and total ASRW was 145/100,000. The incidence of 35-64 years of age is 1.98/100,000, the cumulative incidence of gallbladder cancer at 0-74 years old is 0.16%, and the risk of cumulative incidence of gallbladder cancer is 0.16%. The incidence of men is significantly higher than that of women. The gender ratio of CR, ASRC and ASRW is 0.89, 1.07, and 1.06 in order. With the increase of age in each age group, the incidence of gallbladder cancer has also increased. The age of gallbladder cancer is slightly improved. The overall gallbladder cancer, men and women, and the incidence of each age group have a significant upward trend in 50 years. Conclusion The incidence of Gallbladder and Biliary Tract cancer in the whole population of Qidong City has increased considerably during the past 50 years, with the incidence rate of the higher age group higher than that of the lower age group, and continued attention should be paid to the research of Gallbladder and Biliary Tract cancer prevention and treatment especially for the key populations.

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