| [Objective] Cost-effectiveness and cost-utility analysis were conducted on the lung cancer screening project in urban areas of Anhui Province to provide suggestions for the formulation of lung cancer screening policies in Anhui Province. [Methods] A Markov decision model for Low-Dose Computed Tomography (LDCT) lung cancer screening intervention was established based on on-site survey data and literature data. The development of the population under different interventions was simulated, using saved life years (LYS) and quality-adjusted life years (QALYs) as effectiveness indicators, to conduct cost-effectiveness and cost-utility analyses of different screening strategies. Cost data were discounted at a 3% discount rate. [Results] The screening schemes of once a year, once every two years, once every three years, and once every five years all meet the cost-effectiveness principle for saving one LYS or QALY. Among them, the best screening strategy in terms of cost-effectiveness and cost-utility is the LDCT lung cancer screening strategy once every two years, with costs of 72,441.54 yuan/LYS and 71,050.24 yuan/QALY, respectively. [Conclusion] The LDCT lung cancer screening program demonstrates good cost-effectiveness, with strategies of different screening frequencies being viable options. The optimal screening strategy is screening once every two years. |
