梁永君,井小会,刘玉刚.FOLFIRI与FOLFOX4方案一线治疗晚期大肠癌的疗效观察[J].中国肿瘤,2013,22(3):232-234. |
FOLFIRI与FOLFOX4方案一线治疗晚期大肠癌的疗效观察 |
The Response of FOLFIRI Versus FOLFOX4 Regimens in the First-line Treatment for Advanced Colorectal Cancer |
投稿时间:2012-08-24 |
DOI:10.11735/j.issn.1004-0242.2013.03.A2012247 |
|
 |
中文关键词: 奥沙利铂 氟尿嘧啶 亚叶酸钙 一线治疗 大肠癌 |
英文关键词:oxaliplatin fluorouracil calcium folinate first-line treatment colorectal cancer |
基金项目: |
|
摘要点击次数: 2430 |
全文下载次数: 1321 |
中文摘要: |
摘 要:[目的] 比较FOLFIRI方案与FOLFOX4方案一线治疗晚期大肠癌的疗效和不良反应。[方法] 将56例晚期大肠癌患者随机分为两组:FOLFIRI方案组(n=28)和FOLFOX4方案组(n=28),2个周期后观察疗效和不良反应。[结果] FOLFIRI组有效率(RR)为35.7%,中位肿瘤进展时间(TTP)为7.5个月,中位总生存期(mOS)为15个月,1、2、3年生存率分别为89.29%、73.08%和40.00%;FOLFOX4组RR为39.3%,TTP为7.5个月,mOS为16个月,1、2、3年生存率分别为89.29%、72.00%和45.45%;两组比较各项指标差异无统计学意义(P>0.05)。不良反应中FOLFIRI组腹泻发生率高于FOLFOX4组,神经毒性发生率明显低于FOLFOX4组。[结论] FOLFIRI方案与FOLFOX4方案的疗效相当,都可作为晚期大肠癌的一线标准方案。 |
英文摘要: |
Abstract: [Purpose] To compare the efficacy and toxicity of FOLFIRI and FOLFOX4 regimens in the first-line treatment for advanced colorectal cancer.[Methods] Fifty-six patients with advanced colorectal cancer were randomly divided into two groups: FOLFIRI group(n=28) and FOLFOX4 group(n=28).The response and toxicity were evaluated after 2 cycles of chemotherapy.[Results] In FOLFIRI group the response rate(RR),median time to tumor progression(TTP),median overall survival(mOS) and 1-,2-,3- survival rates were 35.7%,7.5 months,15 months,89.29%,73.08% and 40.00%,respectively; while in FOLFOX4 group those were 39.3%,7.5 months,16 months,89.29%,72.00% and 45.45% respectively.There was no significant difference between the 2 groups(P>0.05). The incidence rate of diarrhea in FOLFIRI group was higher than that in FOLFOX4 group; while the incidence of neurotoxicity was significantly lower than that in FOLFOX4 group. [Conclusion] FOLFIRI and FOLFOX4 regimens have similar treatment response,which can be used as a first-line regimen for advanced colorectal cancer. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |