| 梁永君,井小会,刘玉刚.FOLFIRI与FOLFOX4方案一线治疗晚期大肠癌的疗效观察[J].中国肿瘤,2013,22(3):232-234. |
| FOLFIRI与FOLFOX4方案一线治疗晚期大肠癌的疗效观察 |
| The Response of FOLFIRI Versus FOLFOX4 Regimens in the First-line Treatment for Advanced Colorectal Cancer |
| 投稿时间：2012-08-24 |
| DOI：10.11735/j.issn.1004-0242.2013.03.A2012247 |
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| 中文关键词: 奥沙利铂 氟尿嘧啶 亚叶酸钙 一线治疗 大肠癌 |
| 英文关键词:oxaliplatin fluorouracil calcium folinate first-line treatment colorectal cancer |
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| 中文摘要: |
| 摘 要：［目的］ 比较FOLFIRI方案与FOLFOX4方案一线治疗晚期大肠癌的疗效和不良反应。［方法］ 将56例晚期大肠癌患者随机分为两组：FOLFIRI方案组（n=28）和FOLFOX4方案组(n=28)，2个周期后观察疗效和不良反应。［结果］ FOLFIRI组有效率(RR)为35.7%，中位肿瘤进展时间(TTP)为7.5个月，中位总生存期（mOS）为15个月，1、2、3年生存率分别为89.29%、73.08%和40.00%；FOLFOX4组RR为39.3%，TTP为7.5个月，mOS为16个月，1、2、3年生存率分别为89.29%、72.00%和45.45%；两组比较各项指标差异无统计学意义(P＞0.05)。不良反应中FOLFIRI组腹泻发生率高于FOLFOX4组，神经毒性发生率明显低于FOLFOX4组。［结论］ FOLFIRI方案与FOLFOX4方案的疗效相当，都可作为晚期大肠癌的一线标准方案。 |
| 英文摘要: |
| Abstract: ［Purpose］ To compare the efficacy and toxicity of FOLFIRI and FOLFOX4 regimens in the first-line treatment for advanced colorectal cancer.［Methods］ Fifty-six patients with advanced colorectal cancer were randomly divided into two groups: FOLFIRI group(n=28) and FOLFOX4 group(n=28).The response and toxicity were evaluated after 2 cycles of chemotherapy.［Results］ In FOLFIRI group the response rate(RR)，median time to tumor progression(TTP)，median overall survival(mOS) and 1-，2-，3- survival rates were 35.7%，7.5 months，15 months，89.29%，73.08% and 40.00%，respectively; while in FOLFOX4 group those were 39.3%，7.5 months，16 months，89.29%，72.00% and 45.45% respectively.There was no significant difference between the 2 groups(P＞0.05). The incidence rate of diarrhea in FOLFIRI group was higher than that in FOLFOX4 group; while the incidence of neurotoxicity was significantly lower than that in FOLFOX4 group. ［Conclusion］ FOLFIRI and FOLFOX4 regimens have similar treatment response，which can be used as a first-line regimen for advanced colorectal cancer. |
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